Here's a photo of one of the first applications of the new Tesla 4680 structural battery:
For comparison, behind the cut away mock-up is a mock-up of the old 2170 cell design.
This is from the Berlin Gigafactory public tour. It looks like the battery box completely replaces the floor and is bolted into the cast and sheet metal body. Corrugated cooling channels appear to be placed between every other row of cells. Not shown are the buss bars and the bonding between the top cover/ floor and the top of the cells. There's a lot of DIY potential here, with the right vehicle, with the bolt-in design and structural member aspect of the battery box.