It will electrically work upside down, and with no active cooling being upside down shouldn't matter to cooling, either. I would want to look at where all vents are located.
The battery case is not intended as a load floor - I wouldn't use it that way. I would consider mounting it right side up, and positioning crossmembers to support a load deck above it to miss the humps in the pack. The deck is going to end up really high, if the bottom of the battery pack sits in the original truck box floor or at the height of that floor - the deck will go right over the wheel wells which normally protrude into the truck box.
The battery case is not intended as a load floor - I wouldn't use it that way. I would consider mounting it right side up, and positioning crossmembers to support a load deck above it to miss the humps in the pack. The deck is going to end up really high, if the bottom of the battery pack sits in the original truck box floor or at the height of that floor - the deck will go right over the wheel wells which normally protrude into the truck box.