This is super rough, but better than the crickets we have so far.
F450 is only rated to ~14,000lb GVWR, iirc. The engines in them were 235HP 7.2L diesels. That's 300kW full power up a steep grade, say 6%, at 60mph.
That increase in grade requires about 840 pounds of force, assuming Ford didn't design for gross towing weight. Assume 30" tires...about 1000ft lb. Back that into a 4.56 rear end ratio, direct drive turns ratio is 219 ft lb. Guess it at 2500 RPM gets us 104HP or about 130kW.
Backing that out of the 300kW leaves us with 170kW used at 60MPH if we assume Ford designd the e/f-450 to climb a 6% grade at highway speed at rated GVW.
A lot of assumptions.
Now, to get 100 miles of range, we need 1.67*170 or about 280kWh of battery. Call it 300kWhr for a 90% battery to motive power efficiency. Most of the new chargers are 350kW, so charge in an hour and a bit. Deploy a 3kW solar system at your stops for 6hr a day, and you self charge in...half a month.
3 Tesla 100 packs to go 100miles at full GVWR. 48 modules at 55lb is about 2600lb...call it 3000lb boxed.
That leaves 11,000 lb of curb weight plus payload.
So, it is feasible. $60 grand in batteries, though. A bit cheaper if you go with other choices like Leaf.
Would you rather have $100,000 in an electrified E450 conversion not counting donor and interior work, or pay the same (about $150-175,000) for a diesel motor home?
Yes, you need to stop every hour. But so does Greyhound, lol.