Only thing I can really think of is if the coolant leaks from a hose or something. If they are upside down the box should definitely have a drain hole, otherwise coolant could get on the cell tabs/bms board and cause a short. I believe that was the root cause of the Volt that caught fire at the NHTSA lab several days after the car was in a rollover test. Took that long for the coolant to dry, the residue to start conducting and the cells to discharge beyond safe levels.
Other than that, flipping them might be a bit of a pain so maybe make a tool to support them from the flat surface above the coolant passages so you can hold them while tightening the oem foot clamps (assuming you plan to re-use those?)
Other than that, flipping them might be a bit of a pain so maybe make a tool to support them from the flat surface above the coolant passages so you can hold them while tightening the oem foot clamps (assuming you plan to re-use those?)