I don't have batteries in front so I used the passenger side heater channel to run 10 ga and 16 ga for my charger and charger sense wires from the back seat area to the front where the charger is. I purchased some 1.5" diameter orange flexible plastic conduit to bring those cables up the door jamb area to a spot under the hood near the former gas tank fill tube. I couldn't fit the conduit in the floor heater channels so I used nylon wrap to protect the cables from wear. If I ever but some batteries in front there is still room for two 2/0 cables.
I used the same 1.5" conduit to run through the firewall next to the transmission (behind where the seatback would be) to the motor compartment. The conduit is strapped up high so it will clear the half shafts. I tried putting the conduit through the heater channels but there is a restriction in there and it will not fit. This way they exit at a higher location for the batteries that will go in the back seat area.
I have kept the drivers side channel clear in case I want to install a heater, but that decision will come in nine months after I experience a Southern California winter. I never considered using the center tube because as others have said, it has the shift tube in there.